کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2013508 1067119 2010 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Context-dependent sensitization to ethanol in zebrafish (Danio rerio)
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Context-dependent sensitization to ethanol in zebrafish (Danio rerio)
چکیده انگلیسی

One of the most robust and readily measurable effects of moderate doses of ethanol on zebrafish behavior is locomotor hyperactivity. Two experiments were designed to examine the effects of repeated exposures to ethanol on ethanol-induced locomotor hyperactivity, and to determine whether these effects are context-dependent. Adult, wild-type zebrafish were given repeated exposure to ethanol in the presence of one contextual stimulus (A), while exposed to water in the presence of a second contextual stimulus (B). Exposure to ethanol consistently induced locomotor hyperactivity. After repeated exposures, animals tested with ethanol in the ethanol-paired context (A) showed sensitization of locomotor activity. When tested with ethanol in the unpaired context (B), however, sensitization was not observed. When tested in the absence of ethanol, there were no differences in responding to the paired and unpaired stimuli. This is the first demonstration of ethanol-induced locomotor sensitization in zebrafish. Moreover, this sensitization was context-specific, indicating that learning can modify drug-induced behaviors in zebrafish.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pharmacology Biochemistry and Behavior - Volume 95, Issue 3, May 2010, Pages 278–284
نویسندگان
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