کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2013849 1067133 2008 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Central vs. peripheral administration of ethanol, acetaldehyde and acetate in rats: Effects on lever pressing and response initiation
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Central vs. peripheral administration of ethanol, acetaldehyde and acetate in rats: Effects on lever pressing and response initiation
چکیده انگلیسی

The metabolites of ethanol, acetaldehyde and acetate, are biologically active, and different effects may be produced depending upon the particular metabolite and the route of administration. These studies characterized the effects of intraperitoneal (IP) vs. intraventricular (ICV) administration of ethanol, acetaldehyde, and acetate administered to male Sprague-Dawley rats. Operant behavior was assessed by conducting a detailed temporal analysis of lever pressing with rats responding on a fixed ratio 5 schedule of food reinforcement. IP administration of all three drugs produced a rate-decreasing effect on the total number of responses. Acetaldehyde and acetate were much more potent than ethanol at reducing lever pressing. The interresponse time (IRT) distribution also was more potently altered by IP administration of ethanol metabolites than by ethanol itself. The total lever pressing and IRT distributions of ethanol- and acetaldehyde- treated rats were not significantly affected when these drugs were administered ICV, while acetate produced a marked suppression of fast responses and an increase in pausing. The metabolites of ethanol are more potent than ethanol itself in terms of altering patterns of lever pressing. Thus, the effects of ethanol administration could in part be due to the actions of its biologically active metabolites.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pharmacology Biochemistry and Behavior - Volume 89, Issue 3, May 2008, Pages 304–313
نویسندگان
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