کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2014004 | 1067139 | 2008 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Influence of chronic exercise on reserpine-induced oxidative stress in rats: Behavioral and antioxidant evaluations
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Several neurological diseases are related to oxidative stress (OS) and neurotoxicity. Considering that physical exercise may exert beneficial effects on antioxidant defenses, our objective was to evaluate the influence of a swimming exercise on an OS animal model (reserpine-induced orofacial dyskinesia). In this model, the increased dopamine metabolism can generate OS and neuronal degeneration, causing involuntary movements. The increase in vacuous chewing movements and facial twitching caused by reserpine (1 mg/kg sc) was partially prevented by exercise. An increase in catalase activity and a decrease in GSH levels were observed in the striatum. Physical training did not change the effects of reserpine on catalase, however it partially recovered GSH. Exercise per se caused a significant GSH decrease. There was a positive correlation between catalase and OD (r = 0.41; r = 0.47, P < 0.05) and a negative correlation between GSH and OD (r = 0.61; r = 0.71, P < 0.05). These results reveal the benefit of exercise in attenuating the motor disorder related to OS.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pharmacology Biochemistry and Behavior - Volume 88, Issue 4, February 2008, Pages 465-472
Journal: Pharmacology Biochemistry and Behavior - Volume 88, Issue 4, February 2008, Pages 465-472
نویسندگان
Angélica M. Teixeira, FabÃola Trevizol, Gabriela Colpo, Solange C. Garcia, Mariele Charão, Romaiana P. Pereira, Roselei Fachinetto, João B.T. Rocha, Marilise E. Bürger,