کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2014099 | 1067143 | 2007 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Environmental and immune stressors enhance alcohol-induced motor ataxia in rat
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
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چکیده انگلیسی
Infection is now accepted as a stressor, consequently we sought to compare the short- and longer-term consequences of several environmental stressors versus an endotoxin challenge on alcohol-induced motor ataxia. The present set of studies examined the impact of intermittent electric shock (SHOCK), intermittent cold water swim (ICWS), or lipopolysaccharide (LPS) administration on the motor ataxic effects of an intraperitoneal (i.p.) injection of alcohol (ETOH). In Experiment 1 SHOCK, but not ICWS, enhanced the motor ataxic effects of ethanol at both 2 and 24Â h post-stress. In Experiment 2 administration of LPS did not affect the motor ataxic effects of ETOH 4Â h later, but enhanced the ataxic potency of ETOH 24Â h later. The results indicate that certain environmental and immune stressors have the potential to alter the long-term behavioral reactivity to alcohol. These examples of stress-induced enhancement of the motor ataxic effects of ETOH may have important implications for the development of alcohol dependence.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pharmacology Biochemistry and Behavior - Volume 86, Issue 1, January 2007, Pages 125-131
Journal: Pharmacology Biochemistry and Behavior - Volume 86, Issue 1, January 2007, Pages 125-131
نویسندگان
Robert C. Drugan, Lisa M. Wiedholz, Angela Holt, Stephen Kent, John P. Christianson,