کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2014238 | 1067149 | 2006 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Effects of the CRF1 antagonist antalarmin on cocaine self-administration and discrimination in rhesus monkeys
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Cocaine stimulates the rapid release of ACTH, and by inference, CRF in several species, suggesting that the HPA “stress” axis may contribute to the abuse-related effects of cocaine. The effects of a systemically-active CRF1 receptor antagonist, antalarmin, on cocaine self-administration and cocaine discrimination were examined in rhesus monkeys. Antalarmin's acute (1-10Â mg/kg, IV) and chronic (3.2Â mg/kg IV) effects on IV cocaine self-administration were studied. The acute effects of 3.2Â mg/kg IV antalarmin on the cocaine self-administration dose-effect curve (0.001-0.10Â mg/kg/inj) were also examined. The acute effects of antalarmin (5 and 10Â mg/kg, IM) on the cocaine discrimination dose-effect curve (0.013-1.3Â mg/kg) were examined. Antalarmin did not significantly decrease the reinforcing or the discriminative stimulus effects of cocaine. Acute antalarmin administration produced a dose-dependent but non-significant decrease in self-administration of 0.01Â mg/kg/inj cocaine but did not alter the cocaine dose-effect curve. Chronic daily antalarmin treatment did not significantly decrease cocaine-maintained responding. Antalarmin did not significantly alter either the cocaine discrimination dose-effect curve or the time course of the cocaine-training dose. Antalarmin (10Â mg/kg) produced sedation, suggesting that it was centrally active, however, it did not attenuate cocaine's abuse-related effects in rhesus monkeys.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pharmacology Biochemistry and Behavior - Volume 85, Issue 4, December 2006, Pages 744-751
Journal: Pharmacology Biochemistry and Behavior - Volume 85, Issue 4, December 2006, Pages 744-751
نویسندگان
Nancy K. Mello, S. Stevens Negus, Kenner C. Rice, Jack H. Mendelson,