کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2014344 1067154 2007 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
NAN-190 potentiates the impairment of retention produced by swim stress
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
NAN-190 potentiates the impairment of retention produced by swim stress
چکیده انگلیسی
Exposing rats to stress in the form of forced swim immediately after passive-avoidance training impaired retention. In contrast, exposure to the same stressor 2 h after training failed to impair retention. Systemic administration of the 5-HT1A receptor antagonist NAN-190 (1 mg/kg) immediately after forced swim markedly potentiated the stress-induced impairment of retention. In contrast, NAN-190 failed to affect retention when administered 2 h after forced swim or in forced swim's absence. These findings provide evidence for a NAN-190-sensitive system modulating retention that is 1) activated during a critical period shortly after exposure to swim stress, and 2) protective of memory, thereby limiting the extent to which retention is impaired by experiential stress.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pharmacology Biochemistry and Behavior - Volume 87, Issue 1, May 2007, Pages 73-80
نویسندگان
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