کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2014498 1067161 2006 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effect of the 5-HT6 serotonin antagonist MS-245 on the actions of (−)nicotine
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Effect of the 5-HT6 serotonin antagonist MS-245 on the actions of (−)nicotine
چکیده انگلیسی

The 5-HT6 serotonin receptor antagonist MS-245 neither substitutes for nor antagonizes the discriminative stimulus effects of (−)nicotine. However, MS-245 was shown to enhance the potency of (−)nicotine in Sprague–Dawley rats trained to discriminate 0.6 mg/kg of (−)nicotine from saline vehicle in a typical two-lever drug discrimination paradigm such that a combination of MS-245 (5.0 mg/kg) plus the ED50 dose of (−)nicotine caused the animals to respond as if they had received the training dose of (−)nicotine. MS-245 also potentiated the hypolocomotor actions, but not the antinociceptive effects, of (−)nicotine in mice. The results suggest possible involvement of serotonin-regulated signaling mechanisms in certain behavioral effects of nicotine.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pharmacology Biochemistry and Behavior - Volume 85, Issue 1, September 2006, Pages 170–177
نویسندگان
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