کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2019 97 2010 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Three-dimensional scaffold of electrosprayed fibers with large pore size for tissue regeneration
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی بیو مهندسی (مهندسی زیستی)
پیش نمایش صفحه اول مقاله
Three-dimensional scaffold of electrosprayed fibers with large pore size for tissue regeneration
چکیده انگلیسی

The regeneration of tissues using biodegradable porous scaffolds has been intensely investigated. Since electrospinning can produce scaffolds mimicking nanofibrous architecture found in the body, it has recently gained widespread attention. However, a major problem is the lack of pore size necessary for infiltration of cells into the layers below the surface, restricting cell colonization to the surfaces only. This study describes a novel twist to the traditional electrospinning technology: specifically, collector plates are designed which allow the formation of very thin layers with pore sizes suitable for cell infiltration. The thin samples could be handled without mechanically damaging the structure and could be transferred into cell culture. These thin layers were stacked layer-by-layer to develop thick structures. Thirty day cultures of fibroblasts show attachment and spreading of cells in every layer. This concept is useful in regenerating thick tissues with uniformly distributed cells and others in in vitro cell culture.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Acta Biomaterialia - Volume 6, Issue 12, December 2010, Pages 4734–4742
نویسندگان
, ,