کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2019538 1542211 2015 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The cell secretome, a mediator of cell-to-cell communication
ترجمه فارسی عنوان
مخدر سلولی، یک واسطه ارتباط سلولی به سلول
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
چکیده انگلیسی


• This review briefly summarizes the signaling functions of the secreted metabolites and highlights the role of the secretome of bone marrow stromal cells in polarization of macrophages, development of acute kidney injury, fibrosis and cell senescence.

We are witnessing the emergence of a novel type of biological regulation, namely, the communication between cells via their secreted substances, the secretome. This brief overview is based on the available published data and our own experience. We discuss three vignettes illustrating the importance of communication via the secretome: (1) the secretome of stem cells and its effects in sepsis and systemic inflammatory response; (2) the profibrotic secretomes partially responsible for development of fibrotic complications; and (3) the contribution of senescence-associated secretory products to the propagation of the senescence phenotype. Considering the richness of secretomes of different cells under diverse conditions, it becomes imperative to gain insights into their individual components in an attempt to harness cell secretomes for therapeutic purposes.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Prostaglandins & Other Lipid Mediators - Volume 120, July 2015, Pages 17–20
نویسندگان
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