کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2019538 | 1542211 | 2015 | 4 صفحه PDF | دانلود رایگان |
• This review briefly summarizes the signaling functions of the secreted metabolites and highlights the role of the secretome of bone marrow stromal cells in polarization of macrophages, development of acute kidney injury, fibrosis and cell senescence.
We are witnessing the emergence of a novel type of biological regulation, namely, the communication between cells via their secreted substances, the secretome. This brief overview is based on the available published data and our own experience. We discuss three vignettes illustrating the importance of communication via the secretome: (1) the secretome of stem cells and its effects in sepsis and systemic inflammatory response; (2) the profibrotic secretomes partially responsible for development of fibrotic complications; and (3) the contribution of senescence-associated secretory products to the propagation of the senescence phenotype. Considering the richness of secretomes of different cells under diverse conditions, it becomes imperative to gain insights into their individual components in an attempt to harness cell secretomes for therapeutic purposes.
Journal: Prostaglandins & Other Lipid Mediators - Volume 120, July 2015, Pages 17–20