Isoprostanes and neuroprostanes: Total synthesis, biological activity and biomarkers of oxidative stress in humans

• Total synthesis report of isoprostanes (IsoPs) and neuroprostanes (NeuroPs).
• IsoPs and NeuroPs derived from a non-enzymatic peroxidation of PUFAs bound to phospholipids.
• IsoPs are the most reliable biomarkers of lipid peroxidation in humans and animal models.
• Several IsoPs have also been shown to be biologically active.

Isoprostanes (IsoPs) and neuroprostanes (NeuroPs) are formed in vivo by a free radical non-enzymatic mechanism involving peroxidation of arachidonic acid (AA, C20:4 n-6) and docosahexaenoic acid (DHA, C22:6 n-3) respectively. This review summarises our research in the total synthesis of these lipid metabolites, as well as their biological activities and their utility as biomarkers of oxidative stress in humans.