Lysophosphatidic acid and calcitriol co-operate to promote human osteoblastogenesis: Requirement of albumin-bound LPA

► Lysophosphatidic acid (LPA) is assuming a growing significance in human osteoblast biology. ► Importantly LPA is known to co-operate with calcitriol, an essential factor in bone development. ► Whether LPA and calcitriol might influence osteoblast formation from their mesenchymal progenitors is unknown. ► Herein we present evidence that LPA and calcitriol promote human osteoblast development. ► Our findings extend the potential of LPA as an adjunct for bone repair and regeneration.