Role of the adenosine2A receptor-epoxyeicosatrienoic acid pathway in the development of salt-sensitive hypertension

► Epoxyeicosatrienoic acids (EETs) are renal vasodilator and natriuretic eicosanoids. ► Adenosine-activated renovascular dilatation is mediated via A2A receptor (R) which is linked to increasing EET synthesis. ► The A2A R-EET pathway is upregulated in normotensive rats and contributes to the adaptive response to high salt intake. ► Failure to upregulate the A2A R-EET pathway may contribute to the development of salt-sensitive hypertension.