کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
20213 43163 2015 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effect of oxygen supply on Monascus pigments and citrinin production in submerged fermentation
ترجمه فارسی عنوان
تأثیر مصرف اکسیژن بر رنگدانه های موناسک و تولید سیب زمینی در فرایند غوطه ور شدن
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی بیو مهندسی (مهندسی زیستی)
چکیده انگلیسی

The influence of oxygen supply on Monascus pigments and citrinin production by Monascus ruber HS.4000 in submerged fermentation was studied. For Monascus cultivation with high pigments and low citrinin production, the initial growth phase, mid-stage phase, and later-stage production phase were separated by shifting oxygen supply. The optimal condition for the fermentation process in shake-flask fermentation was a three-stage rotating rate controlled strategy (0–48 h at 150 rpm, 48–108 h at 250 rpm, 108–120 h at 200 rpm) with medium volume of 100 mL added to 250 mL Erlenmeyer flasks at 30°C for 120 h cultivation. Compared to constant one-stage cultivation (medium volume of 100 mL, rotating rate of 250 rpm), the pigments were reduced by 40.4%, but citrinin was reduced by 64.2%. The most appropriate condition for the fermentation process in a 10 L fermentor is also a three-stage aeration process (0–48 h at 300 L/h, 48–96 h at 500 L/h, 96–120 h at 200 L/h) with agitation of 300 rpm at 30°C for 120 h cultivation, and 237.3 ± 5.7 U/mL pigments were produced in 120 h with 6.05 ± 0.19 mg/L citrinin in a 10 L fermentor. Compared to aeration-constant (500 L/h) cultivation, pigment production was increased by 29.6% and citrinin concentration was reduced by 79.5%.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Bioscience and Bioengineering - Volume 119, Issue 5, May 2015, Pages 564–569
نویسندگان
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