کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2022367 1542393 2014 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Prior regular exercise reverses the decreased effects of sleep deprivation on brain-derived neurotrophic factor levels in the hippocampus of ovariectomized female rats
ترجمه فارسی عنوان
ورزش منظم قبل از ورزش باعث کاهش اثرات کاهش محرومیت خواب بر فاکتورهای نوروتروف فاکتور مغز در هیپوکامپ موشهای صحرایی تخمدان شده است.
کلمات کلیدی
محرومیت از خواب، عوامل مغزی نوروتروفیک تمرین فیزیکی، موش ماده
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
چکیده انگلیسی


• SD decreased BDNF protein levels in the hippocampus of ovariectomized (OVX) rats.
• Sleep deprived OVX rats showed a decrease in BDNF mRNA expression in the hippocampus.
• Exercise improved deleterious changes of BDNF levels in sleep deprived OVX rats.

Previous studies indicated that brain-derived neurotrophic factor (BDNF) is the main candidate to mediate the beneficial effects of exercise on cognitive function in sleep deprived male rats. In addition, our previous findings demonstrate that female rats are more vulnerable to the deleterious effects of sleep deprivation on cognitive performance and synaptic plasticity.Therefore, the current study was designed to investigate the effects of treadmill exercise and/or sleep deprivation (SD) on the levels of BDNF mRNA and protein in the hippocampus of female rats.Intact and ovariectomized (OVX) female Wistar rats were used in the present experiment. The exercise protocol was four weeks treadmill running and sleep deprivation was accomplished using the multiple platform method. Quantitative reverse transcriptase-polymerase chain reaction (RT-PCR) and immunoblot analysis were used to evaluate the level of BDNF mRNA and protein in the rat hippocampus respectively.Our results showed that protein and mRNA expression of BDNF was significantly (p < 0.05) decreased after 72 h SD in OVX rats in compared with other groups. Furthermore, sleep deprived OVX rats under exercise conditions had a significant (p < 0.05) up-regulation of the BDNF protein and mRNA in the hippocampus.These findings suggest that regular exercise can exert a protective effect against hippocampus-related functions and impairments induced by sleep deprivation probably by inducing BDNF expression.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Regulatory Peptides - Volumes 194–195, November 2014, Pages 11–15
نویسندگان
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