Neuregulin-1β regulates tyrosine kinase receptor expression in cultured dorsal root ganglion neurons with excitotoxicity induced by glutamate

► Dissociated rat DRG neuronal culture model was established. ► NRG-1β on Trk expression in DRG neurons with Glu-induced toxicity was determined. ► NRG-1β increased TrkA or TrkB, but not TrkC in DRG neurons with Glu-induced toxicity. ► PI3K and ERK1/2 inhibitors either alone or in combination blocked NRG-1β's effects.