Further studies on the effects of intracrine and extracellular angiotensin II on the regulation of heart cell volume. On the influence of aldosterone and spironolactone

►Extracellular Angiotensin II causes cell swelling in failing heart. ►Intracellular Angiotensin II reduces the cell volume. ►Aldosterone increases the cell swelling induced by Angiotensin II. ►Spironolactone inhibits the effect of Angiotensin II on cell volume. ►AT1 receptors' expression is involved in the action of aldosterone and spironolactone.