Angiotensin-converting enzymes (ACE and ACE2) are downregulated in renal tumors

►ACE and ACE2 play an important role in the iRAS. ►ACE and ACE2 have been associated with renal injury. ►ACE and ACE2 activity and protein expression are downregulated in renal neoplasms. ►ACE and ACE2 mRNA levels are downregulated in distal nephron tumors (ChRCC and RO). ►These findings suggest a metabolic imbalance of iRAS in renal neoplastic diseases.