کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2023273 1542445 2007 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Does zaltoprofen antagonize the bradykinin receptors?
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Does zaltoprofen antagonize the bradykinin receptors?
چکیده انگلیسی

Zaltoprofen is a nonsteroidal antiinflammatory drug that has been proposed to inhibit with some selectivity the nociception mediated by the bradykinin (BK) B2 receptor. In order to test the predictive power of this claim, we applied the drug to vascular smooth muscle assays previously found useful to characterize B2 receptor antagonists (contractility, human isolated umbilical vein) or B1 receptor antagonists (contraction, rabbit aorta; relaxation, rabbit mesenteric artery). Zaltoprofen (up to 30 μM) failed to antagonize BK or des-Arg9-BK-induced contraction in the umbilical vein and aorta, respectively. The drug (1 μM) abated des-Arg9-BK-induced, prostaglandin-mediated relaxation of the precontracted mesenteric artery, consistent with its known activity as a cyclooxygenase (COX) inhibitor. However, zaltoprofen (10 μM) did not inhibit kinin-stimulated phospholipase A2 activity in HEK 293 cells expressing recombinant forms of the rabbit B1 or B2 receptors. Nonpeptide antagonists of either receptor subtype were active in this respect. The results do not support that zaltoprofen, a COX inhibitor, antagonizes kinin receptors or influences their signaling with selectivity in the tested systems.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Regulatory Peptides - Volume 140, Issue 3, 3 May 2007, Pages 125–130
نویسندگان
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