کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2023392 1542451 2006 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Oxytocin is expressed throughout the human gastrointestinal tract
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Oxytocin is expressed throughout the human gastrointestinal tract
چکیده انگلیسی

Background/AimSeveral studies have described that oxytocin exerts stimulatory or inhibitory effects on gut functions. Recently, mRNA for oxytocin and its receptor was found throughout the entire human gastrointestinal (GI) tract. The aim of this study was to examine the cellular localization and distribution of the corresponding proteins.Material and methodsFull-thickness biopsies from 24 patients, covering the entire GI tract, were collected during operations at the Department of Surgery in Malmö and Lund. The biopsies were taken from non_affected margins. The biopsies were fixed by immersion, rinsed in buffered sucrose, and kept frozen at  70 °C. Indirect immunofluorescence with primary antibodies to oxytocin and its receptor was used.ResultsOxytocin was expressed in nerve cell bodies and nerve fibres in the myenteric and submucous ganglia all along the GI tract. Immunoreactive nerve cell bodies in myenteric ganglia predominated in the proximal (antrum and duodenum) and distal gut, while those in the submucous ganglia were more numerous in the ileum and colon. The oxytocin receptor was not detectable by two different antibodies in any tissue in the GI tract.ConclusionOxytocin is expressed in the myenteric and submucous ganglia and nerve fibres along the entire human GI tract. The role for oxytocin in the physiology and pathophysiology of the bowel remains to be settled.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Regulatory Peptides - Volume 135, Issues 1–2, 15 July 2006, Pages 7–11
نویسندگان
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