کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2023756 1069803 2009 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Mitochondria as targets for cancer chemotherapy
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Mitochondria as targets for cancer chemotherapy
چکیده انگلیسی

Heterogeneity of tumors dictates an individual approach to anticancer treatment. Despite their variability, almost all cancer cells demonstrate enhanced uptake and utilization of glucose, a phenomenon known as the Warburg effect, whereas mitochondrial activity in tumor cells is suppressed. Considering the key role of mitochondria in cell death, it appears that resistance of most tumors towards treatment can be, at least in part, explained by mitochondrial silencing in cancer cells. This review is devoted to the role of mitochondria in cell death, and describes how targeting of mitochondria can make tumor cells more susceptible to anticancer treatment.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Seminars in Cancer Biology - Volume 19, Issue 1, February 2009, Pages 57–66
نویسندگان
, , ,