کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2024071 | 1069846 | 2008 | 7 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: The cholinergic system and cancer The cholinergic system and cancer](/preview/png/2024071.png)
The finding that the cholinergic system may be present in non-neuromuscular cells and tissues was, at the beginning, not easily accepted by the scientific community (since 1970–1982). Today the entire set of cholinergic molecules and their functions in cell-to-cell communication, mediated by intracellular ion dynamics, is well-established. Nicotinic and muscarinic (nAChR, mAChR) are functionally present on different human cell types and build a part of an autocrine-proliferative network. In synthesis Ach via nAChR or mAChR appears to be involved in the regulation of vital cell functions: proliferation, differentiation, organization of the cytoskeleton, cell–cell contact, ciliary activity, migration, secretion and absorption of ions, water and mucus. Understanding the role of the non-neuronal cholinergic system in different diseases (i.e. inflammation and or cancer) needs to be clarified in more detail, in order to optimize a future targeted-therapy, as well as precautions in the design of interventional drugs.
Journal: Seminars in Cancer Biology - Volume 18, Issue 3, June 2008, Pages 211–217