کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2024214 1069892 2007 14 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Genomic mechanisms and measurement of structural and numerical instability in cancer cells
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Genomic mechanisms and measurement of structural and numerical instability in cancer cells
چکیده انگلیسی

The progression to cancer is often associated with instability and the acquisition of genomic heterogeneity, generating both clonal and non-clonal populations. Chromosomal instability (CIN) describes the excessive rate of numerical and structural genomic change in tumors. Mitotic segregation errors strongly influences copy number, while structural aberrations can occur at unstable genomic regions, or through aberrant DNA repair or methylation. Combined molecular cytogenetic analyses can evaluate cell-to-cell variation, and define the complexity of numerical and structural alterations. Because structural change may occur independently of numerical alteration, we propose the term structural chromosomal instability [(S)-CIN] to distinguish numerical from structural CIN.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Seminars in Cancer Biology - Volume 17, Issue 1, February 2007, Pages 5–18
نویسندگان
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