کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2028267 | 1542731 | 2012 | 7 صفحه PDF | دانلود رایگان |
Twelve new hydroquinones and quinones (4a–c to 7a–c) derived from free or peracetylated bile acids were prepared by a Barton decarboxylation reaction, with subsequent trapping of the resulting free radical by benzoquinone. All new compounds were completely characterized by 2D NMR techniques and screened for antifungal and cytotoxic activity. One of the new hydroquinones (7b) showed promising results against the human pancreatic ductal carcinoma cell line PANC1, with similar cytotoxic activity as the commercial chemotherapy drug doxorubicin.
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► Twelve new quinones and hydroquinones were synthesized from bile acids.
► The key step of the synthesis was a Barton decarboxylation reaction.
► The radicals derived from Barton esters were quenched with benzoquinone.
► The antifungal and cytotoxic activities of the compounds were tested.
► One of the new compounds was highly active against a pancreatic carcinoma cell line.
Journal: Steroids - Volume 77, Issues 1–2, January 2012, Pages 45–51