کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
202873 460626 2014 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Influences on the stability of collagen triple-helix
ترجمه فارسی عنوان
تأثیرات بر ثبات کلاژن سه بعدی هیلیکس
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی مهندسی شیمی (عمومی)
چکیده انگلیسی

Collagen forms a triple helix structure which consists of three tightly coiled polyproline II-type (PPII) strands with the repeating amino acid motif Xaa-Yaa-Gly, where Xaa and Yaa are often proline (Pro) and hydroxproline (Hyp), respectively. The thermal and mechanical stability of the collagen triple-helix is a complex balance between several factors, e.g. sterical influences of substituents, stereoelectronic effects, or interstrand interactions. On the basis of computational studies, we have analyzed the influence of these effects and demonstrate that even comparatively small effects, like the stereoelectronic gauche-effect, and intramolecular hydrogen-bonding can have an impact on the triple-helix stability. In addition, our results suggest that hydrogen bond-like interactions perpendicular to the helix axis increase the stiffness of collagen. Our studies provide a deeper insight into the structure-directing factors in collagenous materials and will help to improve the synthesis of collagen-like biomaterials.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Fluid Phase Equilibria - Volume 362, 25 January 2014, Pages 113–117
نویسندگان
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