کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2032514 1542878 2015 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
In vivo sedative and muscle relaxants activity of Diospyros lotus L
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوشیمی، ژنتیک و زیست شناسی مولکولی (عمومی)
پیش نمایش صفحه اول مقاله
In vivo sedative and muscle relaxants activity of Diospyros lotus L
چکیده انگلیسی

ABSTRACTObjectiveTo evaluate the sedative effect of Diospyros lotus L (D. lotus) extract in mice using the open field and Rota rod tests.MethodsFor the sedative and muscle relaxants activities of extract/fractions of the plant, in-vivo open field and phenobarbitone-induced sleeping time were used, while the Roda rod test was employed in animals for the assessment of muscle relaxant activity.ResultsResults from this investigation revealed that the extracts of D. lotus have exhibited significant sedative effect in mice (45.98%) at 100 mg/kg i.p. When the extract was partitioned with different solvents, the n-hexane fraction was inactive whereas the chloroform fraction was the most active with 82.67% sedative effect at 50 and 100 mg/kg i.p. On the other hand, the ethyl acetate and n-butanol fractions displayed significant sedative effects (55.65% and 40.87%, respectively) at 100 mg/kg i.p. Among the tested extract/fractions, only chloroform and ethyl acetate fractions showed significant (P < 0.05) muscle relaxant activity in the Rota rod test.ConclusionsIn short, our study provided scientific background to the traditional uses of D. lotus as sedative.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Asian Pacific Journal of Tropical Biomedicine - Volume 5, Issue 4, April 2015, Pages 277–280
نویسندگان
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