Antidiabetic and antidiarrhoeal effects on ethanolic extract of Psidium guajava (L.) Bat. leaves in Wister rats

ABSTRACTObjectiveTo evaluate the antidiabetic and the antidiarrhoeal effects of ethanolic extracts of Psidium guajava leave (EEPGL) in Wister rats to support its traditional uses.MethodsOral glucose tolerance test model and alloxan induced diabetic test model were performed to evaluate antidiabetic activity of EEPGL at doses of 1.00, 0.50 and 0.75 g/kg respectively. For antidiarrhoeal effects of EEPGL, castor oil-induced diarrhoea model and gastrointestinal motility test with barium sulphate milk model were also assessed at doses of 750, 500 and 250 mg/kg, respectively.ResultsAdministration of EEPGL at doses 1.00 and 0.50 g/kg significantly (P<0.05) decreased blood glucose levels in oral glucose tolerance test model as well as 0.75 g/kg dose in alloxan induced diabetic test model in Wister rats (P<0.001). Application of EEPGL at doses of 750 and 500 mg/kg showed antidiarrhoeal effect in castor oil-induced diarrhoeal model (P<0.001 and P<0.01, respectively), and 750 mg/kg (P<0.01), 500 and 250 mg/kg (P<0.05) doses in barium sulphate milk model in aforesaid animals.ConclusionsThese results exhibited the significant antidiabetic and antidiarrhoeal activities of ethanolic extracts of Psidium guajava leave in Wister rats.