کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2033075 1542891 2014 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Acute and subacute oral toxicity study on the flavonoid rich fraction of Monodora tenuifolia seed in albino rats
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوشیمی، ژنتیک و زیست شناسی مولکولی (عمومی)
پیش نمایش صفحه اول مقاله
Acute and subacute oral toxicity study on the flavonoid rich fraction of Monodora tenuifolia seed in albino rats
چکیده انگلیسی

ABSTRACTObjectiveTo investigate the effects of the flavonoid rich fraction of Monodora tenuifolia seed on the haematology, histopathology and liver profile of Wistar albino rats.MethodsToxicity study was investigated on the flavonoid rich fraction of Monodora tenuifolia in rats administered different concentrations orally for 28 d using standard laboratory procedures.ResultsThe LD50 of the flavonoid rich fraction was found to be above 5000 mg/kg body weight in mice observed for 48 h. After the Day 14, biochemical markers of liver injury such as serum alanine aminotransferase, and aspartate aminotransferase decreased significantly (P<0.05 at doses of 100 and 200 mg/kg body weight and P<0.01 at 400 mg/kg) while serum alkaline phosphatase increased non-significantly (P>0.05). There was non-significant (P>0.05) effect observed across the groups in the levels of serum total protein, albumin, globulin, urea and creatinine. The result of histological examination showed various degrees of peribiliary hepatitis after the Day 14 which fizzled out after the Day 28.ConclusionsThe result therefore suggests that the seed extract is potentially safe.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Asian Pacific Journal of Tropical Biomedicine - Volume 4, Issue 3, March 2014, Pages 194–202
نویسندگان
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