کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2034909 1543058 2008 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Death mechanism of chronologically aged yeast
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوشیمی، ژنتیک و زیست شناسی مولکولی (عمومی)
پیش نمایش صفحه اول مقاله
Death mechanism of chronologically aged yeast
چکیده انگلیسی

Budding yeast Saccharomyces cerevisiae has two distinct lifespans. The replicative lifespan is defined as the number of progeny cells that a mother cell can have prior to senescence while the chronological lifespan is a measure of the time nondividing cells remain viable. Mechanisms for cells to choose the type of lifespans appropriate to environmental conditions to minimize DNA damage should be critical for maintenance of viability, an interesting question worthy of further investigation. To this end, we hypothesize that chronologically aged cells are defective in the lifespan choosing mechanism so that DNA replication, characteristic of the replicative lifespan, initiates near end of the chronological lifespan. Replication may frequently stall due to the limited resources and oxidative stress, leading to replication fork stall and fatal DNA damage. We will use the 2D DNA gel electrophoresis to examine replication initiation and stall at rDNA in the chronologically aged cells.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioscience Hypotheses - Volume 1, Issue 6, 2008, Pages 287–291
نویسندگان
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