Enhancement of l-cysteine production by disruption of yciW in Escherichia coli

Using in silico analysis, the yciW gene of Escherichia coli was identified as a novel l-cysteine regulon that may be regulated by the transcriptional activator CysB for sulfur metabolic genes. We found that overexpression of yciW conferred tolerance to l-cysteine, but disruption of yciW increased l-cysteine production in E. coli.