Solubility of osthole in a binary system of ethanol and water

The solubility of osthole in a binary system of ethanol and water was measured by UV spectrophotometry from 288.2 to 328.2 K. The solubility of osthole in the system increased with temperature. A synergistic effect appeared at x2 = 0.5527 (equivalent to 80% ethanol, v/v) binary mixtures. Solubility data correlated with a modified Apelblat equation. The enthalpy and entropy of solution of osthole were evaluated using van’t Hoff plots.

► The solubility of osthole in the binary system was investigated.
► The solubility data correlated with a modified Apelblat equation.
► The enthalpy and entropy of solution of osthole were evaluated using van’t Hoff plots.
► A synergistic effect of osthole appeared in a binary mixture of the system of ethanol + water.