کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
204257 460712 2012 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Partitioning of cephalosporins in acetone/NaCl two-phase system
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی مهندسی شیمی (عمومی)
پیش نمایش صفحه اول مقاله
Partitioning of cephalosporins in acetone/NaCl two-phase system
چکیده انگلیسی

Partitioning of several kinds of semi-synthetic cephalosporins in acetone/NaCl two-phase system was investigated. The system is composed of hydrophilic solvent, inorganic salt and water. The phase diagram of acetone/NaCl system was made by titration method. Cephalosporin concentration was determined by HPLC. Experimental results showed that cephalosporin concentration and temperature have a little effect on the partition of cephalosporins. NaCl concentration and acetone concentration affect the partition to a certain extent. When these concentrations increase, cephalosporins move from top phase (acetone phase) to bottom phase (salt phase). The effect of pH on the partition is great. At low pH, cephalosporins stay mainly in top phase. When pH increases to 3.8, most of cephalosporins transfer to bottom phase. It is practicable to extract cephalosporins by adjusting pH of the two-phase system.


► The phase diagram of acetone/NaCl system was made.
► Partition conditions of cephalosporins in this system were investigated.
► The most important factor influencing the partition is solution pH.
► Acetone/NaCl system makes the extraction of cephalosporins possible.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Fluid Phase Equilibria - Volume 319, 14 April 2012, Pages 1–4
نویسندگان
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