کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2048592 | 1074084 | 2009 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Inhibition of hepatic damage and liver fibrosis by brain natriuretic peptide
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Inhibition of hepatic damage and liver fibrosis by brain natriuretic peptide Inhibition of hepatic damage and liver fibrosis by brain natriuretic peptide](/preview/png/2048592.png)
چکیده انگلیسی
Anti-fibrotic and organ protective effects of brain natriuretic peptide (BNP) have been reported. In this study, effects of BNP on liver fibrosis were examined in the carbon tetrachloride (CCl4)-induced liver fibrosis model using BNP-transgenic (Tg) and wild-type (WT) mice. Twice-a-week intraperitoneal injections of CCl4 for 8 weeks resulted in massive liver fibrosis, augmented transforming growth factor (TGF)-β1 and type I procollagen α1 chain (Col1a1) mRNA expression, and the hepatic stellate cell (HSC) activation in WT mice, all of which were significantly suppressed in Tg mice. These observations indicate that BNP inhibits liver fibrosis by attenuating the activation of HSCs.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 583, Issue 12, 18 June 2009, Pages 2067–2070
Journal: FEBS Letters - Volume 583, Issue 12, 18 June 2009, Pages 2067–2070
نویسندگان
Takuhiro Sonoyama, Naohisa Tamura, Kazutoshi Miyashita, Kwijun Park, Naofumi Oyamada, Daisuke Taura, Megumi Inuzuka, Yasutomo Fukunaga, Masakatsu Sone, Kazuwa Nakao,