کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2049255 1074121 2010 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Chaperone-mediated autophagy in health and disease
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
Chaperone-mediated autophagy in health and disease
چکیده انگلیسی

Chaperone-mediated autophagy (CMA) is a lysosomal pathway that participates in the degradation of cytosolic proteins. CMA is activated by starvation and in response to stressors that result in protein damage. The selectivity intrinsic to CMA allows for removal of damaged proteins without disturbing nearby functional ones. CMA works in a coordinated manner with other autophagic pathways, which can compensate for each other. Interest in CMA has recently grown because of the connections established between this autophagic pathway and human pathologies. Here we review the unique properties of CMA compared to other autophagic pathways and its relevance in health and disease.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 584, Issue 7, 2 April 2010, Pages 1399–1404
نویسندگان
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