کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2050479 1074171 2007 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Chemical DNA damage activates p21WAF1/CIP1-dependent intra-S checkpoint
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
Chemical DNA damage activates p21WAF1/CIP1-dependent intra-S checkpoint
چکیده انگلیسی

When cells progressing in G1 phase are irradiated with UV light, two damage checkpoint pathways are activated: CHK1–Cdc25A and p53–p21WAF1/CIP1, both targeting Cdk2 but the latter inducing long lasting inactivation. In similarly irradiated S phase cells, however, p21WAF1/CIP1-dependent checkpoint is largely inactive. We report here that p21-dependent checkpoint can effectively be activated and induce a prolonged S phase arrest with similarly extended inactivation of Cdk2 by association of p21 if mid-S phase cells are damaged with a base-modifying agent instead of UV light, indicating that the poor utilization of p21-dependent checkpoint is not an innate property of S phase cells.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 581, Issue 30, 22 December 2007, Pages 5879–5884
نویسندگان
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