Keywords: متیل متان سولفونات; NSAID; Non-Steroidal Anti-Inflammatory Drug; COX; cyclooxygenases; Px; Piroxicam; CD; Circular Dichroism; DLS; Dynamic Light Scattering; SEM; Scanning Electron Microscope; FTIR; Fourier Transform Infra Red Spectroscopy; EPR; Electron Paramagnetic Resonanc
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Keywords: متیل متان سولفونات; Micronucleus; Liver; Repeated-dose; Methyl methanesulfonate;
Keywords: متیل متان سولفونات; 2-AA; 2-aminoanthracene; 2-NF; 2-nitrofluorene; 9-AA; 9-aminoacridine; ARA; arachidonic acid; bw; body weight; CBPI; cytokinesis-blocked proliferation index; DHA; docosahexaenoic acid; DMSO; dimethyl sulfoxide; F1; first generation; FOB; functional observ
Keywords: متیل متان سولفونات; Genotoxicity; Cobalt compounds; Overall assessment; 2-AA; 2-aminoanthracene; 2NF; 2-nitrofluorene; 4-NOPD; nitro-o-phenylenediamine; 6Â TG; 6-thioguanine; 8-OH-dG; 8-hydroxy-2-deoxyguanosine; 9AA; 9-aminoacridine; AAF; artificial alveolar fluid; B[a]P; be
Keywords: متیل متان سولفونات; ATM; ataxia telangiectasia mutated; CBMN; cytokinesis-block micronucleus; DMSO; dimethyl sulfoxide; EDTA; ethylenediaminetetraacetic acid; F-actin; filamentous actin; FBS; fetal bovine serum; FCM; flow cytometry; FS; forward scatter; ICP-OES; inductively
Keywords: متیل متان سولفونات; AD; Alzheimer's disease; AP site; apurinic/apyrimidinic site; APE1; apurinic/apyrimidinic endonuclease 1; Aβ; amyloid beta; BER; base excision repair; CaMKII; Ca2 +/Calmodulin-Dependent Protein Kinase II; CDK; cyclin-dependent kinase; CREB; cAMP respons
Keywords: متیل متان سولفونات; AMD; age-related macular degeneration; CE; capillary electrophoreis; CPP; conditioned place preference; CK; creatine kinase; C. sativus L.; Crocus sativus L.; FAB-MS; fast atom bombardment-mass spectrometry; G. fructus; Gardenia fructus; G. jasminoides; G
In vitro safety pharmacology evaluation of 2-hydroxybenzylamine acetate
Keywords: متیل متان سولفونات; Salicylamine; Metabolism; Toxicity; Human; Rat; Rabbit; γKA; γ-ketoaldehyde; 2-AA; 2-aminoanthracene; 2-HOBA; 2-hydroxybenzylamine; 4-NOPD; 4-nitro-o-phenylenediamine; CYP; cytochrome p450; hERG; human ether-a-go-go; HPLC; high-performance liquid chroma
Collaboration in the actions of Brh2 with resolving functions during DNA repair and replication stress in Ustilago maydis
Keywords: متیل متان سولفونات; HR; homologous recombination; HU; hydroxyurea; MMS; methyl methanesulfonate; UV; ultraviolet light; BRCA2; Blm; Mus81; Gen1; DNA repair; Replication stress;
Drug toxicity profiling of a Saccharomyces cerevisiae deubiquitinase deletion panel shows that acetaminophen mimics tyrosine
Keywords: متیل متان سولفونات; APAP; acetyl-para-aminophenol, acetaminophen; AMAP; acetyl-meta-aminophenol; CHX; cycloheximide; FTY720; fingolimod; HU; hydroxyurea; MMS; methyl methanesulfonate; Ubiquitin; Deubiquitinase; Toxicity; Tyrosine; Amino acids; Starvation; APAP;
Trichostatin A inhibits deacetylation of histone H3 and p53 by SIRT6
Keywords: متیل متان سولفونات; Sirtuin; NAD+-dependent deacetylation; Inhibition; NAD+; nicotinamide adenine dinucleotide; NAM; nicotinamide; AADPR; O-acetyl-ADP-ribose; TSA; trichostatin A; HDAC; histone deacetylase; TFA; trifluoroacetic acid; MMS; methyl methanesulfonate;
Low doses of DNA damaging agents extend Saccharomyces cerevisiae chronological lifespan by promoting entry into quiescence
Keywords: متیل متان سولفونات; CFU; colony-forming units; CLS; chronological lifespan; DHE; dihydroethidium; DHR; dihydrorhodamine; DiOC6; 3,3â²-dihexyloxacarbocyanine iodide; FOA; 5-fluoroorotic acid; HU; hydroxyurea; MMS; methyl methanesulfonate; NQ; non-quiescent; 4NQO; 4-nitroquin
Assessment of genotoxic activity of oleoresins and leaves extracts of six Copaifera species for prediction of potential human risks
Keywords: متیل متان سولفونات; B.W.; Body weight; BNCMN; Binucleated cells with micronuclei; BOD; Biochemical oxygen demand; CBPI; Cytokinesis-block proliferation index; DMEM; Dulbecco's modified eagle medium; DMSO; Dimethyl sulfoxide; GC/MS; Gas Chromatography-Mass Spectrometry; HAM
Short communicationAn assay to detect DNA-damaging agents that induce nucleotide excision-repairable DNA lesions in living human cells
Keywords: متیل متان سولفونات; NER; nucleotide excision repair; BER; base excision repair; UV; ultraviolet light; Cisplatin; cis-diamminedichloroplatinum (II); MMS; methyl methanesulfonate; DNA lesions; Nucleotide excision repair; Xeroderma pigmentosum;
Lack of genotoxicity in vivo for food color additive Allura Red AC
Keywords: متیل متان سولفونات; Food color; Allura Red AC; FD&C Red no. 40; E129; INS 129; Genotoxicity; CP; Cyclophosphamide; EUEFSA; European Food Safety Authority; EU; European Union; FD&C; Food, Drug, and Cosmetic; GLP; Good Laboratory Practices; INS; International Numbering System;
An evaluation of DNA damage in human lymphocytes and sperm exposed to methyl methanesulfonate involving the regulation pathways associated with apoptosis
Keywords: متیل متان سولفونات; DNA damage; Methyl methanesulfonate; Genotoxicity; Apoptotic pathways;
Review ArticleRole of the oxidized form of XRCC1 in protection against extreme oxidative stress
Keywords: متیل متان سولفونات; XRCC1; DNA polymerase β; Methyl methanesulfonate; Hydrogen peroxide; Glutathione depletion; PAR;
Cell cycle-dependent positive and negative functions of Fun30 chromatin remodeler in DNA damage response
Keywords: متیل متان سولفونات; CPT; camptothecin; DDC; DNA damage checkpoint; DDT; DNA damage tolerance; DSB; double stranded DNA break; G6PD; Glucose-6-phosphate dehydrogenase; HR; homologous recombination; HU; hydroxyurea; MMS; methyl methanesulfonate; ssDNA; single stranded DNA; TLS
The dynamics of histone H2A ubiquitination in HeLa cells exposed to rapamycin, ethanol, hydroxyurea, ER stress, heat shock and DNA damage
Keywords: متیل متان سولفونات; DNA damage; ER stress; Heat shock; Histone H2A; Stress response; Ubiquitin; ER; endoplasmic reticulum; hH2A; histone H2A; HU; hydroxyurea; MMS; methyl methanesulfonate; Tg; thapsigargin; Tm; tunicamycin; Rap; rapamycin; Ub; ubiquitin;
Yap1 and Skn7 genetically interact with Rad51 in response to oxidative stress and DNA double-strand break in Saccharomyces cerevisiae
Keywords: متیل متان سولفونات; DSB; double-strand break; SSB; single-strand break; ROS; reactive oxygen species; HR; homologous recombination; NHEJ; non-homologous end joining; BER; base excision repair; NER; nucleotide excision repair; PQ; paraquat; PHL; phleomycin; HU; hydroxyurea; M
RNF138 interacts with RAD51D and is required for DNA interstrand crosslink repair and maintaining chromosome integrity
Keywords: متیل متان سولفونات; HR; homologous recombination; CFA; colony forming assay; NT; N-terminus; ssDNA; single-stranded DNA; ICL; interstrand crosslink; DSB; double-strand break; MEF; mouse embryo fibroblasts; MMC; mitomycin C; MMS; methyl methanesulfonate; PTM; post-translation
Evaluation of the genotoxicity/mutagenicity and antigenotoxicity/antimutagenicity induced by propolis and Baccharis dracunculifolia, by in vitro study with HTC cells
Keywords: متیل متان سولفونات; CBMN; Cytokinesis-blockage micronucleus test; CHO; Chinese hamster ovary cells; EEBD; Ethanolic extract of Baccharis dracunculifolia; EEGP; Ethanolic extract of green propolis; FBS; Foetal bovine serum; HTC; Hepatoma tissue culture cells; MMS; Methyl meth
Leishmania major and Trypanosoma cruzi present distinct DNA damage responses
Keywords: متیل متان سولفونات; Leishmania major; Trypanosoma cruzi; DNA damage response; Anti-silencing factor 1; Methyl methanesulfonate; Gamma irradiation;
Inactivation of Pif1 helicase causes a mitochondrial myopathy in mice
Keywords: متیل متان سولفونات; COX; cytochrome c oxydase; SDH; succinate dehydrogenase; NADH-TR; nicotinamide adenine dinucleotide dehydrogenase tetrazolium reductase; mtDNA; mitochondrial DNA; OXPHOS; oxidative phosphorylation; LX-PCR; long extension-PCR; mPIF67; mitochondrial PIF1 is
Cytotoxic and genotoxic effects of ethanolic extract of Euphorbia hyssopifolia L. on HepG2 cells
Keywords: متیل متان سولفونات; HepG2; human hepatoma cell culture; MTT assay; colorimetric MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] assay; CBMN assay; cytokinesis-block micronucleus assay; FBS; fetal bovine serum; DMSO; dimethyl sulfoxide; PBS; phosphate buffe
Evaluation of methyl methanesulfonate, 2,6-diaminotoluene and 5-fluorouracil: Part of the Japanese center for the validation of alternative methods (JaCVAM) international validation study of the in vivo rat alkaline comet assay
Keywords: متیل متان سولفونات; In vivo rat comet assay; In vivo mammalian alkaline comet assay; JaCVAM validation study; Methyl methanesulfonate; 2,6-Diaminotoluene; 5-Fluorouracil;
Allium cepa and Tradescantia pallida bioassays to evaluate effects of the insecticide imidacloprid
Keywords: متیل متان سولفونات; IMI; Imidacloprid; USEPA; United States Environmental Protection Agency; MI; Mitotic index; CAI; Chromosomal aberration index; CAs; Chromosomal aberrations; MN; Micronuclei; CB; Chromosome breaks; MMS; Methyl methanesulfonate; CHO; Chinese Hamster Ovary;
DNA polymerase β-dependent cell survival independent of XRCC1 expression
Keywords: متیل متان سولفونات; DNA polymerase β; XRCC1; Methyl methanesulfonate; PARP inhibitor; Camptothecin
LAMMER kinase contributes to genome stability in Ustilago maydis
Keywords: متیل متان سولفونات; FACS; fluorescence activated cell sorting; HR; homologous recombination; HU; hydroxyurea; MMS; methyl methanesulfonate; UV; ultraviolet;
Caenorhabditis elegans EXO-3 contributes to longevity and reproduction: Differential roles in somatic cells and germ cells
Keywords: متیل متان سولفونات; AP; apurinic/apyrimidinic; C. elegans; Caenorhabditis elegans; H2O2; hydrogen peroxide; MMS; methyl methanesulfonate; NaHSO3; sodium bisulfite; THF; tetrahydrofuranyl; ARP; aldehyde reactive probe; AP site; AP endonuclease; C. elegans; EXO-3; Longevity; R
Glyceraldehyde-3-phosphate dehydrogenase is required for efficient repair of cytotoxic DNA lesions in Escherichia coli
Keywords: متیل متان سولفونات; AP sites; abasic sites (apurinic/apyrimidinic); BER; base excision repair; BM; bleomycin; CAA; casein acid hydrolysate; CFUs; colony-forming units; Endo; endonuclease; Exo; exonuclease; GAPDH; glyceraldehyde-3-phosphate dehydrogenase; Gph; phosphoglycolat
Disruption of SUMO-targeted ubiquitin ligases Slx5-Slx8/RNF4 alters RecQ-like helicase Sgs1/BLM localization in yeast and human cells
Keywords: متیل متان سولفونات; HU; hydroxyurea; Y2H; yeast-2-hybrid; DSB; double-strand break; HR; homologous recombination; STUbL; SUMO-targeted ubiquitin ligase; SUMO; small ubiquitin-like modifier; YFP; yellow fluorescent protein; CFP; cyan fluorescent protein; RFP; red fluorescent
Cadmium treatment suppresses DNA polymerase δ catalytic subunit gene expression by acting on the p53 and Sp1 regulatory axis
Keywords: متیل متان سولفونات; AP; abasic site; APE1; apurinic/apyrimidinic endonuclease 1; BER; base excision repair; Cd; cadmium; CNS; central nervous system; DNA LigI; DNA ligase I; MMS; methyl methanesulfonate; OGG1; 8-oxoguanine DNA glycosylase; Polβ; DNA polymerase β; Polδ; po
Comparison of the biological effects of MMS and Me-lex, a minor groove methylating agent: Clarifying the role of N3-methyladenine
Keywords: متیل متان سولفونات; AP; apurinic/apyrimidinic; apn1apn2; AP endonucleases 1 and 2 defective; BER; base excision repair; 3-mA; N3-methyladenine; 3-m-c3A; 3-methyl-3-deazaadenine; mag1; 3-methyladenine-DNA glycosylase 1 defective; Me-lex; {1-methyl-4-[1-methyl-4-(3-methoxysulf
ATMIN is required for the ATM-mediated signaling and recruitment of 53BP1 to DNA damage sites upon replication stress
Keywords: متیل متان سولفونات; Replication stress; 53BP1; ATM; ATMIN; MEFs; mouse embryonic fibroblasts; Aph; aphidicolin; IR; ionizing radiation; Gy; Gray; MMS; methyl methanesulfonate; HU; hydroxyurea; NCS; neocarzinostatin; DAPI; diamidino-2-phenylindole; HR; homologous recombinatio
Nicotine, cotinine, and β-nicotyrine inhibit NNK-induced DNA-strand break in the hepatic cell line HepaRG
Keywords: متیل متان سولفونات; 8-MOP; 8-methoxypsoralen; dH2O; deionosed water; HBECS; human bronchial epithelial cells; HPB; 4-oxo-4-(3-pyridyl) 1-butanol; HPLC; high pressure liquid chromatography; IARC; International Agency for the Research on Cancer; NNK; 4-(methylnitrosamino)-1-(3
In vitro and in vivo genotoxicity assessment of HI-6 dimethanesulfonate/oxime
Keywords: متیل متان سولفونات; DMS; dimethyl sulfoxide; AChE; acetyl cholinesterase; Ach; acetylcholine; PAM-2; pralidoxime; GF; cyclosarin; MMS; methyl methanesulfonate; CPA; cyclophosphamide; TFT; trifluorothymidine; DMH; dimethylhydrazine; RTG; relative total growth; PCE; polychroma
Safety evaluation of the human-identical milk monosaccharide sialic acid (N-acetyl-d-neuraminic acid) in Sprague-Dawley rats
Keywords: متیل متان سولفونات; 2-AA; 2-aminoanthracene; 2-NF; 2-nitrofluorene; 9-AA; 9-aminoacridine; ARA; arachidonic acid; bw; body weight; DHA; docosahexaenoic acid; F1; first generation; FOB; functional observational battery; GD; gestation day; GLP; Good Laboratory Practice; ICH; I
Genotoxic potential and in vitro tumour-promoting potential of 2-dodecylcyclobutanone and 2-tetradecylcyclobutanone, two radiolytic products of fatty acids
Keywords: متیل متان سولفونات; 2-ACBs; 2-alkylcyclobutanones; 2-dDCB; 2-dodecylcyclobutanone; 2-tDCB; 2-tetradecylcyclobutanone; 2-tDeCB; 2-(tetradec-5â²-enyl)-cyclobutanone; AOM; azoxymethane; SA; stearic acid; PA; palmitic acid; AF-2; 2-(2-furyl)-3-(5-nitro-2-furyl) acrylamide; 2AA;
Lipid peroxidation product 4-hydroxy-2-nonenal modulates base excision repair in human cells
Keywords: متیل متان سولفونات; 4-Hydroxy-2-nonenal; HNE-DNA adducts; Base excision repair; Ligation, OGG1, TDG, ANPG, APE1; Acr; acrolein; ANPG; alkyl-N-purine glycosylase; AP-site; apurinic/apyrimidinic site; APE1; AP-site endonuclease; BER; base excision repair; BSA; bovine serum a
Pre-clinical safety evaluation of the synthetic human milk, nature-identical, oligosaccharide 2â²-O-Fucosyllactose (2â²FL)
Keywords: متیل متان سولفونات; AG ratio; albumin/globulin ratio; Alb; albumin; ALAT; alanine amino-transferase; ALP; alkaline phosphatase; ASAT; aspartate aminotransferase; Bili; total bilirubin; Ca; calcium; Chol; total cholesterol; Creat; creatinine; CP; cyclophosphamide; DRF; dose r
Physical mapping and cloning of RAD56
Keywords: متیل متان سولفونات; MMS; methyl methanesulfonate; YFP; yellow fluorescent protein; NBRP; National Bioresource Project Japan; cM; centimorgan; T; tetratype; NPD; non-parental ditype; YPD; yeast extract peptone dextrose; SC; synthetic complete; bp; base pair; AU; arbitrary uni
Genotoxicity of pyrroloquinoline quinone (PQQ) disodium salt (BioPQQâ¢)
Keywords: متیل متان سولفونات; 2AA; 2-aminoanthracene; AF-2; 2-(2-furyl)-3-(5-nitro-2-furyl) acrylamide; B[a]P; benzo[a]pyrene; bw; body weight; CHL; Chinese hamster lung; DMSO; dimethyl sulfoxide; GSH; glutathione; ICH; International Conference on Harmonization; ICR-191; -methoxy-6-ch
Preventing oxidation of cellular XRCC1 affects PARP-mediated DNA damage responses
Keywords: متیل متان سولفونات; DNA polymerase β; XRCC1; PARP-1; Methyl methanesulfonate; PARP inhibitor; Poly(ADP-ribose);
Development of a new application of the comet assay to assess levels of O6-methylguanine in genomic DNA (CoMeth)
Keywords: متیل متان سولفونات; BER; base excision repair; BG; O6-benzylguanine; Mx; methoxyamine; MMS; methyl methanesulfonate; MMR; mismatch repair; MNU; N-methyl-N-nitrosourea; MPG; N-methylpurine-DNA glycosylase; O6meG; O6-methylguanine; MGMT; O6-methylguanine-DNA methyltransferase;
DNA alkylation lesions and their repair in human cells: Modification of the comet assay with 3-methyladenine DNA glycosylase (AlkD)
Keywords: متیل متان سولفونات; AlkD; Methyl methanesulfonate; DNA alkylation; DNA glycosylase; In vitro repair; Cellular repair; Comet assay
Sea urchin coelomocytes are resistant to a variety of DNA damaging agents
Keywords: متیل متان سولفونات; AP sites; apurinic or apyrimidinic sites; BaP; benzo[a]pyrene; BER; base excision repair; CMFSW-E; calcium and magnesium-free sea water with EDTA; H2O2; hydrogen peroxide; MMS; methyl methanesulfonate; UV; ultraviolet; Abasic sites; DNA damage; Sea urchin
Characterization of a Trypanosoma brucei Alkb homolog capable of repairing alkylated DNA
Keywords: متیل متان سولفونات; αKG; α-ketoglutarate; MMS; methyl methanesulfonate; ODPA; ortho-phenylenediamine; TbABH; AlkB homolog from Trypanosoma brucei; Trypanosoma brucei; DNA repair; Oxidative demethylation; α-Ketoglutarate; Ferrous ion;
Role of damage-specific DNA polymerases in M13 phage mutagenesis induced by a major lipid peroxidation product trans-4-hydroxy-2-nonenal
Keywords: متیل متان سولفونات; trans-4-Hydroxy-2-nonenal; HNE-DNA adducts; Mutations; NER; DNA repair; M13 phage SOS-dependent mutations; Pol II, Pol IV and Pol V; EH; 2,3-epoxy-4-hydroxynonanal; HNE; trans-4-hydroxy-2-nonenal; IPTG; isopropyl-β-d-thiogalactopyranoside; LPO; lipid per
Methyl methanesulfonate induces apoptosis in p53-deficient H1299 and Hep3B cells through a caspase 2- and mitochondria-associated pathway
Keywords: متیل متان سولفونات; MMS; methyl methanesulfonate; DSB; double strand break; MMP; mitochondrial membrane potential; TAp73; transactivation competent p73; DNp73; dominant negative p73; Methyl methanesulfonate; p53; Caspase 2; gammaH2AX; Apoptosis;