Characterization of a Trypanosoma brucei Alkb homolog capable of repairing alkylated DNA

► Trypanosoma brucei encodes a homolog of Escherichia coli AlkB, which repairs alkylation damage of DNA. ► TbABH belongs to the Fe(II) and alpha-ketoglutarate dioxygenase superfamily. ► TbABH binds DNA, with a preference for alkylated DNA. ► TbABH complements an E. coli alkB knockout.