کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2052090 | 1074221 | 2006 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Anandamide inhibits Cdk2 and activates Chk1 leading to cell cycle arrest in human breast cancer cells
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Anandamide inhibits Cdk2 and activates Chk1 leading to cell cycle arrest in human breast cancer cells Anandamide inhibits Cdk2 and activates Chk1 leading to cell cycle arrest in human breast cancer cells](/preview/png/2052090.png)
چکیده انگلیسی
This study was designed to determine the molecular mechanisms underlying the anti-proliferative effect of the endocannabinoid anandamide on highly invasive human breast cancer cells, MDA-MB-231. We show that a metabolically stable analogue of anandamide, Met-F-AEA, induces an S phase growth arrest correlated with Chk1 activation, Cdc25A degradation and suppression of Cdk2 activity. These findings demonstrate that Met-F-AEA induced cell cycle blockade relies on modulated expression and activity of key S phase regulatory proteins. The observed mechanism of action, already reported for well-known chemotherapeutic drugs, provides strong evidence for a direct role of anandamide related compounds in the activation of cell cycle checkpoints.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 580, Issue 26, 13 November 2006, Pages 6076–6082
Journal: FEBS Letters - Volume 580, Issue 26, 13 November 2006, Pages 6076–6082
نویسندگان
Chiara Laezza, Simona Pisanti, Elvira Crescenzi, Maurizio Bifulco,