کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2052443 | 1074230 | 2005 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Direct interaction between metastasis-associated protein 1 and endophilin 3
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Direct interaction between metastasis-associated protein 1 and endophilin 3 Direct interaction between metastasis-associated protein 1 and endophilin 3](/preview/png/2052443.png)
چکیده انگلیسی
The yeast two-hybrid system was used to search for partners of mouse metastasis-associated protein 1 (Mta1). Screening of a cDNA library prepared from mouse embryo yielded positive clones coding for endophilin 3. The site of interaction was suggested to be the SH-3-binding domain of Mta1 and SH-3 domain of endophilin 3. This interaction was confirmed by GST pull-down assay in vitro and immunoprecipitation in vivo. The Mta1 and endophilin 3 transcripts were highly expressed in testis and brain. But, Mta1 localized mainly in nucleus and to a lesser extent in cytoplasm while endophilin 3 localized mainly in cytoplasm. If Mta1 functions in cytoplasm, it might be involved in the regulation of endocytosis mediated by endophilin 3.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 579, Issue 17, 4 July 2005, Pages 3731–3736
Journal: FEBS Letters - Volume 579, Issue 17, 4 July 2005, Pages 3731–3736
نویسندگان
Yuko Aramaki, Katsuhiro Ogawa, Yasushi Toh, Takahiro Ito, Nobuyoshi Akimitsu, Hiroshi Hamamoto, Kazuhisa Sekimizu, Kimihiko Matsusue, Akira Kono, Haruo Iguchi, Soichi Takiguchi,