کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2053357 1074273 2005 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Superoxide determines nitric oxide uptake rate by vascular smooth muscle cells
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
Superoxide determines nitric oxide uptake rate by vascular smooth muscle cells
چکیده انگلیسی

Nitric oxide (NO) is generated in endothelial cells, which diffuses to vascular smooth muscle cells (SMCs), activates soluble guanylyl cyclase, and leads to blood vessel dilation. However, this scenario does not explain how SMCs are capable of competing with erythrocytic hemoglobin for NO in vivo. Here, we have developed a competition experiment to determine the NO uptake rate by SMCs and demonstrated that the SMC-NO uptake rate is positively dependent on intracellular superoxide levels. In addition, the superoxide-elicited NO influx is able to enhance cGMP production in SMCs. Our findings imply that vascular SMCs, in vivo, may use superoxide to compete with erythrocytic hemoglobin for NO and obtain the NO bioactivity.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 579, Issue 20, 15 August 2005, Pages 4349–4354
نویسندگان
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