کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2071072 1078720 2012 15 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Amplified release through the stimulus triggered degradation of self-immolative oligomers, dendrimers, and linear polymers
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوتکنولوژی یا زیست‌فناوری
پیش نمایش صفحه اول مقاله
Amplified release through the stimulus triggered degradation of self-immolative oligomers, dendrimers, and linear polymers
چکیده انگلیسی

In recent years, numerous delivery systems based on polymers, dendrimers, and nano-scale assemblies have been developed to improve the properties of drug molecules. In general, for the drug molecules to be active, they must be released from these delivery systems, ideally in a selective manner at the therapeutic target. As the changes in physiological conditions are relatively subtle from one tissue to another and the concentrations of specific enzymes are often quite low, a release strategy involving the amplification of a biological signal is particularly attractive. This article describes the development of oligomers, dendrimers, and linear polymers based on self-immolative spacers. This new class of molecules is designed to undergo a cascade of intramolecular reactions in response to the cleavage of a trigger moiety, resulting in molecular fragmentation and the release of multiple reporter or drug molecules. Progress in the development of these materials as drug delivery vehicles and sensors will be highlighted.

Figure optionsDownload high-quality image (127 K)Download as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Advanced Drug Delivery Reviews - Volume 64, Issue 11, August 2012, Pages 1031–1045
نویسندگان
, , ,