کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2071119 1078725 2012 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Polycation-based nanoparticle delivery of RNAi therapeutics: Adverse effects and solutions
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوتکنولوژی یا زیست‌فناوری
پیش نمایش صفحه اول مقاله
Polycation-based nanoparticle delivery of RNAi therapeutics: Adverse effects and solutions
چکیده انگلیسی

Small interfering RNA (siRNA) that silence genes by the process of RNA interference offers a new therapeutic modality for disease treatment. Polycation-based nanoparticles termed polyplexes have been developed to maximise extracellular and intracellular siRNA delivery, a key requirement for enabling the clinical translation of RNAi-based drugs. Medical applications are dependent on safety; therefore, detailed investigation into potential toxicity to the cell or organism is required. This review addresses potential adverse effects arising from cellular and tissue interactions, immune stimulation and altered gene expression that can be associated with the assembled polyplex or the polycation and siRNA component parts. A greater understanding of the cellular mechanisms involved allows design-based solutions for rationale development of safe, effective and clinically relevant polyplex-based RNAi drugs.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Advanced Drug Delivery Reviews - Volume 64, Issue 15, December 2012, Pages 1717–1729
نویسندگان
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