کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2072297 1078952 2008 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Forward genetic analysis of TLR-signaling pathways: An evaluation
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوتکنولوژی یا زیست‌فناوری
پیش نمایش صفحه اول مقاله
Forward genetic analysis of TLR-signaling pathways: An evaluation
چکیده انگلیسی

Forward genetic approaches have contributed to our understanding of how the host senses infectious agents such as bacteria, viruses and fungi. Beginning with the initial discovery of Toll-like receptors (TLRs) as primary sensors involved in the recognition of microbial components, our laboratory has taken a forward genetic approach, using N-ethyl-N-nitrosourea (ENU) mutagenesis in mice, to decipher TLR-signaling pathways. This long term effort has helped to elucidate the circuitry of these pathways, identified new molecules, and disclosed new functions for known molecules. Here we review some of the more important insights developed from this approach and discuss its prospects.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Advanced Drug Delivery Reviews - Volume 60, Issue 7, 29 April 2008, Pages 824–829
نویسندگان
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