کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2084566 1545393 2008 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Physicochemical properties and biocompatibility of N-trimethyl chitosan: Effect of quaternization and dimethylation
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوتکنولوژی یا زیست‌فناوری
پیش نمایش صفحه اول مقاله
Physicochemical properties and biocompatibility of N-trimethyl chitosan: Effect of quaternization and dimethylation
چکیده انگلیسی

The aim of this research was to investigate the effect of degrees of quaternization (DQ) and dimethylation (DD) on physicochemical properties and cytotoxicity of N-trimethyl chitosan (TMC). TMC was synthesized by reductive methylation of chitosan in the presence of a strong base at elevated temperature and polymer characteristics were investigated. The number of methylation process and duration of reaction were demonstrated to affect the DQ and DD. An increased number of reaction steps increased DQ and decreased DD, while an extended duration of reaction increased both DQ and DD. The molecular weight of TMC was in the range of 60–550 kDa. From the Mark–Houwink equation, it was found that TMC in 2% acetic acid/0.2 M sodium acetate behaved as a spherical structure, approximating a random coil. The highest solubility was found with TMC of an intermediate DQ (40%) regardless of DD and molecular weight. The effect of DD on the physicochemical properties and cytotoxicity was obviously observed when proportion of DD to DQ was higher than 1. TMC with relatively high DD showed reduction in both solubility and mucoadhesion and hence decreased cytotoxicity. However, the influence of DD was insignificant when DQ of TMC was higher than 40% at which physicochemical properties and cytotoxicity were mainly dependent upon DQ.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmaceutics and Biopharmaceutics - Volume 70, Issue 2, October 2008, Pages 563–571
نویسندگان
, , , ,