کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2115383 | 1084592 | 2007 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Defective acute apoptotic response to genotoxic carcinogen in small intestine of APCMin/+ mice is restored by sulindac
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Defective acute apoptotic response to genotoxic carcinogen in small intestine of APCMin/+ mice is restored by sulindac Defective acute apoptotic response to genotoxic carcinogen in small intestine of APCMin/+ mice is restored by sulindac](/preview/png/2115383.png)
چکیده انگلیسی
The effect of APC loss on azoxymethane (AOM)-induced apoptosis and cell proliferation, as well as their regulation by sulindac was examined in colon and small intestine in APCMin/+ mice. APCMin/+ mice showed increased epithelial proliferation in all regions, with significant impairment of apoptosis in small intestine, but not in colon. Sulindac administration restored defective apoptosis to normal. As the apoptotic defect occurred at the major site of intestinal tumor formation in APCMin/+ mice and as it was restored to normal by a proven chemopreventive agent, this defect in apoptosis might be a key biological consequence of APC dysfunction contributing to tumor formation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Letters - Volume 248, Issue 2, 18 April 2007, Pages 234-244
Journal: Cancer Letters - Volume 248, Issue 2, 18 April 2007, Pages 234-244
نویسندگان
Ying Hu, Richard K. Le Leu, Graeme P. Young,