کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2139718 | 1087913 | 2008 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Release of cytochrome c from mitochondria precedes Bax translocation/activation in Triton X-100-induced apoptosis
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
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چکیده انگلیسی
The precise mechanisms by which sublytic concentrations of detergents induce apoptosis remain unclear. Recent studies reported the ability of nonionic detergents such as Triton X-100 to induce conformational change of Bax to the active form in vitro. Here we investigated whether activation of Bax might play a role in Triton X-100-induced apoptosis in cells. Although Bax translocation/activation was inhibited by caspase inhibitors, cytochrome c release from mitochondria was not affected in Triton X-100-induced apoptosis in U-937 cells. These results demonstrate that translocation/activation of Bax occurs downstream of cytochrome c release and caspase activation in Triton X-100-induced apoptosis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Leukemia Research - Volume 32, Issue 3, March 2008, Pages 445–453
Journal: Leukemia Research - Volume 32, Issue 3, March 2008, Pages 445–453
نویسندگان
Hirofumi Sawai, Naochika Domae,