کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2141619 | 1088293 | 2012 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Parity and risk of lung cancer in women: Systematic review and meta-analysis of epidemiological studies
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
IQRSTROBEISI - آی اس آیParity - برابریStrengthening the Reporting of Observational Studies in Epidemiology - تقویت گزارش مطالعات مشاهداتی در اپیدمیولوژیRelative risk - خطر نسبیLung cancer - سرطان ریهNSCLC - سرطان ریوی غیر سلول کوچکNon-small cell lung cancer - سرطان غیر سلول کوچک ریهWomen's health - سلامت زنان confidence interval - فاصله اطمینانMeta-analysis - فرا تحلیل Meta-analysis Of Observational Studies in Epidemiology - متاآنالیز مطالعات مشاهداتی در اپیدمیولوژیinter-quartile range - محدوده بین محوریSystematic review - مرور سیستماتیکMoose - گوزن شمالی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Multiple studies have assessed parity as a risk factor for lung cancer but results have been inconclusive. We searched MEDLINE (through August 2010) and the Institute of Scientific Information Web of Knowledge database (through April 2011) to identify studies investigating the association of parity with lung cancer and allowing the calculation of dose-response trends using a linear model. Between-study heterogeneity was assessed using Cochran's Q statistic and the I2 index. Summary per-child relative risks (RRs) with their 95% confidence interval (CI) were estimated using random effects meta-analysis. Sixteen eligible studies (8077 lung cancer patients; 350,295 unaffected individuals) provided data for meta-analysis. There was significant between-study heterogeneity (p < 0.001; I2 = 73%). The summary per livebirth RR was 0.98 (95% CI, 0.95-1.02), indicating no effect of parity on lung cancer risk. Results were consistent in case-control (n = 11), RR = 0.99 (95% CI, 0.94-1.04), and cohort studies (n = 5), RR = 0.97 (95% CI, 0.92-1.03). Studies not including small-cell lung cancer patients found a borderline protective effect of parity, RR = 0.94 (95% CI, 0.88-1.00). In contrast, no effect was observed in studies including small-cell lung cancer patients, RR = 1.00 (95% CI, 0.98-1.03); p for difference = 0.05. Overall, there was little evidence of a dose-response relationship between increasing number of livebirths and lung cancer; however, studies have produced heterogeneous results. Future studies should include analyses in well-defined histological disease subgroups.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Lung Cancer - Volume 76, Issue 2, May 2012, Pages 150-158
Journal: Lung Cancer - Volume 76, Issue 2, May 2012, Pages 150-158
نویسندگان
Issa J. Dahabreh, Thomas A. Trikalinos, Jessica K. Paulus,