The vapor pressure and vaporization enthalpy of R-(+)-menthofuran, a hepatotoxin metabolically derived from the abortifacient terpene, (R)-(+)-pulegone by correlation gas chromatography

• The vaporization enthalpy and vapor pressure of R-(+) menthofuran is evaluated.
• The normal boiling temperature is predicted and compared to experimental and predicted values.
• A vapor pressure equation as a function of temperature for menthofuran is evaluated.

The vapor pressure as a function of temperature and its vaporization enthalpy at T = 298.15 K of R-(+)-menthofuran, a substance metabolically derived from R-(+)-pulegone that is both a flavoring agent at low concentrations and a hepatotoxin at larger ones, is evaluated by correlation-gas chromatography. A vapor pressure p/Pa = (36 ± 12) has been evaluated at T = 298.15 K, and a normal boiling temperature of Tb/K = 482.4 K is predicted. A boiling temperature of Tb/K = 374.3 compares with the literature value of Tb/K = 371.2 at reduced pressure, p/kPa = 2.93. The vaporization enthalpy of (56.5 ± 3.0) kJ·mol−1 compares to an estimated value of (57.8 ± 2.9) kJ·mol−1.