Measurement and correlation of solubility of cefmenoxime hydrochloride in pure solvents and binary solvent mixtures

• Solubility of cefmenoxime hydrochloride in pure and binary solvents was determined.
• The experimental solubility data were correlated by thermodynamic models.
• A model was employed to calculate the melting temperature of cefmenoxime hydrochloride.
• Mixing thermodynamic properties of cefmenoxime hydrochloride were calculated.

The solubility of cefmenoxime hydrochloride in pure solvents and binary solvent mixtures was measured at temperatures from (283.15 to 313.15) K by using the UV spectroscopic method. The results reveal that the solubility of cefmenoxime hydrochloride increases with increasing temperature in all solvent selected. The solubility of cefmenoxime hydrochloride reaches its maximum value when the mole fraction of isopropanol is 0.2 in the binary solvent mixtures of (isopropanol + water). The modified Apelblat equation and the NRTL model were successfully used to correlate the experimental solubility in pure solvents while the modified Apelblat equation, the CNIBS/R–K model and the Jouyban–Acree model were applied to correlate the solubility in binary solvent mixtures. In addition, the mixing thermodynamic properties of cefmenoxime hydrochloride in different solvents were also calculated based on the NRTL model and experimental solubility data.