Biocompatible choline based ionic salts: Solubility in short-chain alcohols

• Biocompatible ionic liquids based on choline esters were synthesized in this work.
• Solubility of choline and choline esters based ionic salt in alcohols were measured.
• Activity coefficients were calculated.
• Experimental data were correlated by means of the semi-empirical Grant equation.

In this work, we report data on solubility of choline chloride and choline acetate in short-chain linear alcohols (ethanol, 1-propanol and 1-butanol) at various temperatures. Furthermore, we synthesize two choline derivatives: hydrogen choline chloride glutarate ([CholGlut][Cl]) and hydrogen choline chloride succinate ([CholSucc][Cl]). Their characterization and solubility in short-chain alcohols as a function of temperature are also included. Activity coefficients were calculated and their comparisons with ideal solutions were discussed. The experimental data were correlated successfully by means of the semi-empirical Grant equation.