Solubilities of evodiamine in twelve organic solvents from T = (283.2 to 323.2) K

The values of the solubility of evodiamine in chloroform, dichloromethane, acetone, ethyl acetate, 1-butanol, isopropanol, ethanol, methanol, ethyl ether, cyclohexane, n-pentane and n-hexane were measured at T = (283.2, 293.2, 303.2, 313.2, and 323.2) K. The solubility of evodiamine in all the organic solvents studied increases with the increase of the temperature. The experimental solubility values were correlated by a simplified thermodynamic equation and the modified Apelblat equation. The values of the dissolution enthalpy and entropy of evodiamine in all organic solvents were calculated using the van’t Hoff equation. The findings showed that the dissolution process was endothermic and entropy-driven. These data of solubility can be used to guide the processes of extraction, purification in the industry.

► The solubilities of evodiamine in twelve organic solvents are measured.
► The experimental solubility data are correlated by two equations.
► The simplified thermodynamic equation and the modified Apelblat equation.
► The dissolution enthalpy and entropy were calculated using van’t Hoff equation.